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KMID : 0370220100540040232
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Yakhak Hoeji
2010 Volume.54 No. 4 p.232 ~ p.239
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Effects of Acanthopanax koreanum Extracts on Anticancer Related Cytokine Secretions
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Lyu Su-Yun
Park Won-Bong
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Abstract
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Stems and roots of Acanthopanax koreanum Nakai were extracted with water and treated on immune cells in order to determine their immunomodulatory activites. Various Th-1 type cytokines were measured using ELISA including interleukin (IL)-2, IL-12, interferon-gamma (IFN-), and tumor necrosis factor-alpha (TNF-) secreted by dendritic cells, T-cells, intestinal epithelial cells, natural killer cells, and macrophages. As a result, there was a significant increase in IL-12 and IFN-, secretion, but there was no change in the secretion of TNF-. Additionally T-cells slightly increased the secretion of IL-2, but there was a significant increase of IL-2 in intestinal epithelial cells. Therefore, our results suggest that A. koreanum Nakai may act as an immunomodulator by stimulating the cell-mediated immunity which can help the immune system defend against infections or cancer cells.
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KEYWORD
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Acanthopanax koreanum, Cytokines, IL-2, IL-12, IFN-
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